Yes, you can configure the sensor parameters through the DUO API. We currently expose the following parameters that can be updated through the Device API:

Exposure (%) – Changes the exposure or amount of light per unit area. (Directly tied to framerate)
Gain (%) – Boosts the resulting signal (recommended to limit usage as noise increases)
LEDs (%) – Control of the power given to the LED array (only available on MLX devices)

Beyond the parameters the Device API provides full methods to configure framerate, resolution and binning. This allows for a wide range of potential capturing configurations. For full documentation of configurations available please refer to the API Docs (EnumResolutions).